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Wednesday, July 8, 2020 | History

2 edition of molecular mechanisms of haemopoietic growth factor action found in the catalog.

molecular mechanisms of haemopoietic growth factor action

A.A Akinsanya

molecular mechanisms of haemopoietic growth factor action

by A.A Akinsanya

  • 120 Want to read
  • 15 Currently reading

Published by UMIST in Manchester .
Written in English


Edition Notes

StatementA.A. Akinsanya ; supervised by A.D. Whetton.
ContributionsWhetton, A.D., Biochemistry.
ID Numbers
Open LibraryOL21429121M

1. Introduction. Hematopoiesis refers to the process of development of immature precursor cells into various mature and functional blood cells, which initiates from the self-renewing multipotent hematopoietic stem cells (HSCs) [1, 2].This biological process involves accurate coordination of cellular proliferation, differentiation, and survival of progenitor cells to maintain hematopoietic. "Hematopoietic growth factors have revolutionized the treatment of patients with a spectrum of cancers and benign bone marrow disorders. This text addresses the mechanism of action and clinical impact of these cytokines. Leading investigators in the field provide and update of current state of knowledge and future challenges.".

Vigon I, Mornon JP, Cocault L, et al: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. U.S.A. , PubMed CrossRef Google Scholar. ISBN: X OCLC Number: Description: xv, pages: illustrations ; 24 cm. Contents: pt. I --Introduction to the hematopoietic growth factors / Gary H. Lyman and David C. Dale --Early-acting hematopoietic growth factors: biology and clinical experience / Stephen J. Szilvassy --Granulocyte colony .

Introduction to hematopoietic growth factors: a general overview / George Morstyn and MaryAnn Foote --Animal models of hematopoietic growth factor perturbations in physiology and pathology / Graham J. Lieschke --The Jak/Stat pathway of cytokine signaling / Ben A. Croker and Nicos A. Nicola --Small-molecule and peptide agonists: a literature.   Phosphatidylinositolkinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous efforts have been dedicated to the development of drugs targeting PI3K signaling, many of which are currently employed in clinical trials evaluation, and .


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Molecular mechanisms of haemopoietic growth factor action by A.A Akinsanya Download PDF EPUB FB2

Sandra E. Juul, Robert D. Christensen, in Avery's Diseases of the Newborn (Tenth Edition), Overview of Hematopoietic Cytokines. Hematopoietic growth factors can be classified into two groups: those responsible for the regulation of myeloid and erythroid growth and differentiation, called colony-stimulating factors, and those concerned with immunity, called lymphokines.

Hematopoietic Growth Factor Dependent Cell Line Lymphokine Action Mast Cell Precursor Bone Marrow Colony These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm by: Haemopoietic growth factors stimulate a number of consensus biochemical and molecular events regardless of the specificity detailed by unique ligand and receptor structures.

Analysis of three distinct colony stimulating factors, CSFs (IL-3, G-CSF, GM-CSF) molecular mechanisms of haemopoietic growth factor action book the lymphocytotropic growth factor IL-2 reveal remarkable similar distal subcellular biochemical signals although Cited by: 2.

Farrar, D. Ferris and D. Linnekin Haemopoietic growth factor regulation of protein kinases and genes associated with cell proliferation Discussion A. Dunn and A. Wilks Contributions of autocrine and non-autocrine mechanisms to tumorigenicity in a murine model for leukaemia Discussion 15 5 berween haemopoietic growth factor receptors is of interest because it provides an explanation for the similar biological effects of the growth factors despite their apparent structural dissimilarity at the amino acid level.

Presumably, as information on the tertiary structure of the growth factors becomes available, similar receptor­. HEMATOPOIETIC GROWTH factors (HGFs) bind to specific cell surface receptors and rapidly activate cellular tyrosine kinases or intrinsic receptor tyrosine kinase many cases, the receptor itself becomes tyrosine phosphorylated, and phosphorylation sites in the receptor lead to recruitment of SH2 containing proteins that can activate downstream signaling pathways.

Mechanisms of action of erythropoietin in the immature brain. The fact that Epo has biological functions beside erythropoiesis was discovered in the early the s, when Epo mRNA was detected in the brain in response to hypoxia. 30 Ischemic or other metabolic stressors can induce Epo and EpoR expression in animal models, 35 and also in human disease.

36, 37 Whereas. Expression and action of G-CSF in vivo. Healthy individuals express low G-CSF levels in serum (range, hematopoietic growth factor activity in. Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor available through recombinant DNA technology, they hold tremendous potential for medical uses when a person's natural ability to form blood cells is diminished or defective.

Recombinant erythropoietin (EPO) is very effective in treating the diminished red blood cell. Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.

Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. Takashi Kato, in Handbook of Hormones, Abstract.

Hematopoietic growth factors have the ability to promote the proliferation and differentiation of hematopoietic progenitors derived from hematopoietic stem cells in hematopoietic lineages.

The common structural feature displays four-α-helical bundle structure. Phylogeny and evolution of the molecular structure.

Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL. however, the cells are dependent on hematopoietic growth factors.

On a molecular level, the BCR/ABL translocation is well characterized. there may not be any the mechanisms of its action is not well understood. It dramatic difference of. Molecular events associated with the action of haemopoietic growth factors WILLIAM L.

FARRAR1, STUART W. EVANS1, ANNICK HAREL-BELLAN1 and DOUGLAS K. FERRIS2 1 Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, National Cancer Institute, BuildingRoom A, Frederick, MDUSA.

In the hematopoietic system, survival, proliferation, and differentiation of cells are regulated by a plethora of growth factors ().The effect of erythropoietin (EPO) on the generation of red blood cells is well known.

The hematopoietic growth factor thrombopoietin (TPO) stimulates megakaryopoiesis and thrombocyte formation (, 5, 6).During. The structure and function of each factor is covered in detail, as well as its receptor and postreceptor mechanism of action and its possible role in neoplastic processes.

The book also explores the present state of the knowledge about megakaryocyte growth factors and macrophage-derived growth factors. The introduction of recombinant DNA technology triggered a flurry of studies and an information explosion, which confirmed hematopoiesis is mediated by a series of hematopoietic growth factors (HGF) that acts individually and in various combinations involving complex feedback mechanisms.

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases.

This number can be dramatically increased, or mobilized, by a wide variety of stimuli including hematopoietic growth factors, chemotherapy, and certain chemokines. Mobilization regimens utilizing hematopoietic growth factors alone recently have become popular because they avoid exposure to cytotoxic chemotherapy.

In Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics, leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future : Hardcover.

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about the molecular mechanisms of the nervous system effect. distinct mechanisms of action on bone marrow HSC niches and.

VIP as a growth-promoting factor for hematopoietic stem/progeni.Granulocyte colony-stimulating factor: Molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis Article Literature Review in Cytokine 42(3) July with.Enormous number of Hematopoietic growth factors like CSF, GCSF, and GMCSF have been cloned, purified and produced in Recombinant human GCSF is a Hematopoietic growth factor, extensively used in Cancer therapy to treat Neutropenia and .